Rare Mutation Triples Alzheimer's Risk
Bartolomeo Eustachi: Peripheral Nervous System, c. 1722 by brain_blogger
License (according to Flickr): Attribution License
License (according to Flickr): Attribution License
The mutation, in an immunoregulatory gene called TREM2, was more usual in Alzheimer's disease clients than in the general 85-and-older population in Iceland, according to Dr. Kari Stefansson of deCode Genetics in Reykjavik, Iceland, and associates. Since of the gene's feature within the central nervous system, the mutation "may lead to an increased predisposition to Alzheimer's disease through impaired containment of inflammatory processes," the researchers wrote online in the New England Journal of Medicine. Read this tale on www.medpagetoday.com. Such procedures have been implicated in Alzheimer's disease formerly, they noted. In reality, the so-called amyloid theory of the disease holds that brain inflammation is the "downstream effect" of the build-up of beta-amyloid protein plaques, Stefansson and associates wrote.
Keywords:
disease Alzheimer mutation the mutation Kari Stefansson central nervous system old age cognitive decode genetics cognitive function TREM2 the disease general population New England control groups nursing home poorer proteins frequencies the age loss-of-function amyloid Icelanders Reykjavik inflammation containment impaired sequences genome steeper beta-amyloid Norway common no sign Netherlands theory Germany performance the frequency resultsPeople:
Dr. Kari Stefansson
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| 0 | "downstream effect" of the accumulation of beta-amyloid protein plaques, Stefansson and colleagues wrote. ... |
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HealthCondition: Alzheimer's disease
Overall Sentiment: -0.135657
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A mutation found in about one in 200 Icelanders older than 85 raised the risk of developing Alzheimer's disease threefold, researchers said.
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Rare Mutation Triples Alzheimer's Risk
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